SARAH WYNIA-SMITH

EDUCATION AND TRAINING

B.A. 2003, Biology and Chemistry, Northwestern College, IA
M.S. 2005, Physiology, Laboratory of Gail Robertson, University of Wisconsin-Madison
Ph.D., 2009, Physiology, Laboratory of Gail Robertson, University of Wisconsin-Madison
Postdoc, 2009-2011, Bryan Krantz Laboratory, University of California-Berkeley
Postdoc, 2012-2014, Michael Marletta Laboratory, Scripps Research Institute

PUBLICATIONS

Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E. Identification of protein targets of S-nitroso-Coenzyme A-mediated S-nitrosation using chemoproteomics. ACS Chemical Biology (2023). doi: 10.1021/acschembio.3c00654. PMID: 38159293.

Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Kumar Prinja R, Corbett JA, Smith BC. N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic ß-cells. Frontiers in Endocrinology. 2022: 13:923925. DOI: 10.3389/fendo.2022.923925.

Kalous KS, Wynia-Smith SL, Smith BC. Sirtuin oxidative post-translational modifications. Front Physiol. 2021, 12:763417. DOI:10.3389/fphys.2021.763417 PMID: 34899389. PMCID: PMC8652059

Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC. "Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia." Blood Advances. 2020, 22;4(18):4494-4507. doi: 10.1182/bloodadvances.2020001609. PMID: 32946569; PMCID: PMC7509873.

Kalous KS, Wynia-Smith SL, Summers SB, Smith BC. "Human sirtuins are differentially sensitive to nitrosating agents and other cysteine oxidants." Journal of Biological Chemistry. 2020, 295 (25), 8524-8536.  doi: 10.1074/jbc.RA119.011988. PMID: 32371394; PMCID: PMC7307208.

Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. “Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.” ACS Chemical Biology. 2020, 15, 4, 1036-1049. doi: 10.1021/acschembio.0c00058. PMID: 32149490, PMCID: PMC7271629.

Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA. “Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes”. Journal of Biological Chemistry. 2018, 293, 6282-96.

Wynia-Smith SL, Smith BC. “Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases”. Nitric Oxide. 2017, 63, 52-60. doi: 10.1016/j.niox.2016.10.001. PMID: 27720836.

Kalous KS, Wynia-Smith SL, Olp MD, Smith BC. “Mechanism of Sirt1 NAD⁺-dependent Deacetylase Inhibition by Cysteine S-nitrosation”. Journal of Biological Chemistry. 2016, 291 (49), 25398-410. doi: 10.1074/jbc.M116.754655. PMID: 27756843, PMCID: PMC5207242.

Zhou Y*, Wynia-Smith SL*, Couvertier, SM, Kalous KS, Marletta MA, Smith BC*, Weerapana E. “Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2”. Cell Chemical Biology. 2016, 23(6), 727-37. doi: 10.1016/j.chembiol.2016.05.008, PMID: 27291402, PMCID: PMC4920707. *Equal contribution.

Shteyer E*, Edvardson S*, Wynia-Smith SL*, Pierri CL*, Zangen T*, Hashavya S, Begin M, Yaacov B, Cinamon Y, Koplewitz BZ, Vromen A, Elpeleg O, Smith BC. “Truncating Mutation in the Nitric Oxide Synthase 1 Gene Is Associated with Infantile Achalasia”. Gastroenterology. 2015, 148(3), 533-536. doi: doi.org/10.1053/j.gastro.2014.11.044. PMID: 25479138.

Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA. “Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes”. Journal of Biological Chemistry. 2018, 293(17), 6282-96. doi: 10.1074/jbc.M117.817700. PMID: 29483187, PMCID: PMC5925818.

Underbakke ES, Surmeli NB, Smith BC, Wynia-Smith SL, Marletta MA. “Nitric oxide signaling”. Comprehensive Inorganic Chemistry II. 2013, Vol. 3, 241-262.