Dan Sprague, M.D., Ph.D.


B.S. 2011, Biochemistry & Molecular Biology, Chemistry; University of Miami

Ph.D. 2016, Chemistry, Laboratory of Jeff Johnston, Vanderbilt University

M.D. 2021, Medical College of Wisconsin


Yahya, NA, Lanham, J, Sprague, DJ, Palygin, O, McCorvy, JD, Marchant, JS. Molecular and cellular basis of praziquantel action in the cardiovascular system. AJP Cell Physiol, 2023, doi: 10.1152/ajpcell.00520.2022. PMID: 36622066.

Rohr, CM, Sprague, DJ, Park SK, Malcolm, NJ, Marchant, JS. Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity. Proc. Natl Acad. Sci., 2023;120, 1.  doi: 10.1073/pnas.2217732120 PMID: 36574686.

AbuEid, M, Keyes, RF, McAllister, D, Peterson, F, Pulikkal-Kadamberi, I, Sprague, DJ, Chaluvally-Raghavan, P, Smith, BC, Dwinell, MB. Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin. iSCIENCE 2022, 25, 12, 105670. doi: 10.1016/j.isci.2022.105670 PMID: 36567718.

Gunaratne, G.S., Rebbeck, R.T., McGurran, L.M., Yan, Y., Arzua, T., Frolkis, T., Sprague, D.J., Bai, X., Cornea, R.L., Walseth, T.F., Marchant, J.S. Identification of a dihydropyridine scaffold that blocks ryanodine receptors. iSCIENCE 2022, 25, 1, 103706. DOI: 10.1016/j.isci.2021.103706

Sprague DJ, Getschman AE, Fenske TG, Volkman FB, Smith BC. Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. ACS Med Chem Lett. 2021, 12, 11, 1773-1782. DOI: 10.1021/acsmedchemlett.1c00388.

Sprague DJ, Johnston JN. "Substituted Imidazole Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator." Organic Letters. 2020, 22, 21, 8496-8499. PMID: 33054232.

Goetz CJ, Sprague DJ, Smith BC. "Development of activity-based probes for the protein deacylase Sirt1." Bioorganic Chemistry. 2020, 104:104232. doi: 10.1016/j.bioorg.2020.104232.  PMID: 32911193. PMCID: PMC7686039.

Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. “Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.” ACS Chemical Biology. 2020, 15, 4, 1036-1049. doi: 10.1021/acschembio.0c00058. PMID: 32149490, PMCID: PMC7271629.

Sprague DJ, Singh A, Johnston JN. "Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with a-alkyl-substitution." Chemical Science. 2018, 9, 2336-2339.

Arnold DH, Penrod CH, Sprague DJ, Hartert TV. "Count on It! Accurately measured respiratory rate is associated with lung function and clinical severity in children with acute asthma exacerbations." Journal of Pediatrics. 2016 Aug;175:236-236.e1. doi:10.1016/j.jpeds.2016.04.081. PMID:27255859

Sprague DJ, Nugent BM, Yoder RA, Vara BA, Johnston JN. "Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis." Organic Letters. 2015 Feb 20;17(4):880-3. doi: 10.1021/ol503626w

Narcis MJ, Sprague DJ, Captain B, Takenaka N. "Enantio- and periselective nitroalkene Diels-Alder reaction." Organic Biomolecular Chemistry. 2012 Dec 14;10(46):9134-6. doi: 10.1039/c2ob26674a. PMID:23104427

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