Karina Bursch, Ph.D.
M.D./Ph.D. Student
Medical Scientist Training Program (MSTP)
MCW Cancer Center Graduate Fellow
NIH Ruth L. Kirschstein F30 Graduate Fellow
kbursch@mcw.edu
EDUCATION AND TRAINING
Ph.D. 2025, Biochemistry, Medical College of Wisconsin
B.S. 2019, Biochemistry, The Catholic University of America
PUBLICATIONS
Bursch KL, Jorge SD, Catlin AE, Nunez R, LeClaire MD, Licklider J, Urrutia R, and Smith BC. Structural Genomics Defines PBRM1 Bromodomain Variant Function in ccRCC. Human Mutation (2026). 10.1/humu/924621. PMID: 42559237. PMCID: PMC13439403.
Nuñez R, Bursch KL, Makowski S, Xue M, Cozzolino KA, Shishodia S, Keyes RF, Zhu N, and Smith BC. Polybromo-1 Bromodomain Inhibitor Selectivity is Mediated by a Unique Ligand-Binding Pocket. ACS Medicinal Chemistry Letters (2025). doi: 10.1021/acsmedchemlett.5c00352. PMID: 41089488. PMCID: PMC12516376.
Nord JN, Makowski SJ, Sidlowski PFW, Bursch KL, Corbett JA, and Smith BC. BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-kB targets that promote inflammation in β-cells. Journal of Biological Chemistry (2025). doi: 10.1016/j.jbc.2025.110358. PMID: 40505864.
Olp MD, Bursch KL, Wynia-Smith SL, Nuñez R, Goetz CJ, Jackson V, Smith BC. Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains. Journal of Biological Chemistry (2025). doi: 10.1016/j.jbc.2025.108289. PMID: 39938804.
Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC. Cancer-associated Polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. Journal of Biological Chemistry (2024). doi: 10.1016/j.jbc.2024.107146. PMID: 38460939.
Bursch KL, Goetz CJ, Smith BC. Current Trends in Sirtuin Activator and Inhibitor Development. Molecules (2024) doi:10.3390/molecules29051185.
Bursch KL, Olp MD, Smith BC. Analysis of continuous enzyme kinetic data using ICEKAT. Methods in Enzymology (2023) doi: 10.1016/bs.mie.2023.06.019. PMID: 37858527, PMCID: PMC10691744.
Shishodia S, Nunez R, Stormier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. Journal of Medicinal Chemistry. 2022, 65, 20, 13714-13735. doi: 10.1021/acs.jmedchem.2c00864
Sharma P, Alsharif S, Bursch K, Parvathaneni S, Anastasakis DG, Chahine J, Fallatah A, Nicolas K, Sharma S, Hafner M, Kallakury B & Chung BM. "Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors." Scientific Reports. 2019 October 10. PMID 31601969
